Anterograde dendritic transport

Across TCGA patient cohorts, RNA activity of the Anterograde dendritic transport pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STAU2, ARFGEF1, and OXR1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Anterograde dendritic transport activity versus STAU2 in BRCA (Pearson r = 0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	STAU2 →	+0.441	+0.074	<.001	<.001	3	8
BRCA	ARFGEF1 →	+0.488	+0.076	<.001	<.001	3	7
GBM	OXR1 →	+0.438	+0.070	<.001	<.001	3	7
BRCA	ANK3_S959 →	+0.928	+0.065	.004	.008	3	6
COAD	NCOA2 →	+0.329	+0.034	.002	.004	2	7
BRCA	NCOA2_S699 →	+0.437	+0.067	.002	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098937 vs STAU2 — BRCA

Explore this scatter interactively →