Anterograde dendritic transport

Across TCGA cell cohorts, RNA activity of the Anterograde dendritic transport pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF3B, KIF5A, and PLAGL2, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KIF3B grouped by Anterograde dendritic transport-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	KIF3B →	-0.525	-1.932	<.001	<.001	3	11
BREAST	KIF5A →	-0.188	-1.084	<.001	<.001	3	9
BLOOD_Leukemia	PLAGL2 →	-0.210	-1.350	<.001	<.001	3	8
BLOOD_Myeloma	KIF17 →	-0.316	-1.322	.001	.007	3	8
LUNG_NSCLC_LUAD	TRIP4 →	-0.280	-0.924	.001	.003	3	8
LARGE_INTESTINE	FLOT2 →	-0.269	-1.396	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KIF3B by Anterograde dendritic transport activity — BONE

Explore this box plot interactively →