Anterograde dendritic transport

Across TCGA cell cohorts, RNA activity of the Anterograde dendritic transport pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MED12, EFNB3, and RCOR1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MED12 grouped by Anterograde dendritic transport-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MED12 →	+0.365	+0.116	.002	.007	2	7
BREAST	EFNB3 →	-0.335	-0.132	.001	.001	3	5
BLOOD_Leukemia	RCOR1 →	+0.465	+0.180	.008	.001	3	5
LUNG_NSCLC_LUSC	KMT5C →	-0.213	-0.179	.004	.002	3	5
LUNG_NSCLC_LUSC	ARHGEF6 →	+0.296	+0.228	.003	<.001	3	5
LUNG_SCLC	SIRT2 →	+0.235	+0.147	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MED12 by Anterograde dendritic transport activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →