Vesicle-mediated transport between endosomal compartments

Across TCGA cell cohorts, RNA activity of the Vesicle-mediated transport between endosomal compartments pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTMA, EFEMP1, and GPR87, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vesicle-mediated transport between endosomal compartments activity versus PTMA in PANCREAS (Pearson r = -0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PTMA →	-0.704	-0.169	.001	.001	3	6
LIVER	EFEMP1 →	+3.850	+0.911	<.001	.006	3	5
LUNG_NSCLC_LUAD	GPR87 →	+1.820	+0.679	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	FAM117B →	-0.836	-1.453	.002	.006	3	4
UPPER_AERODIGESTIVE_TRACT	UFC1 →	-0.854	-0.972	<.001	.003	3	4
LARGE_INTESTINE	MTHFD2L →	-0.517	-0.546	.006	.005	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098927 vs PTMA — PANCREAS

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