Membrane repolarization during ventricular cardiac muscle cell action potential

Across TCGA patient cohorts, RNA activity of the Membrane repolarization during ventricular cardiac muscle cell action potential pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are POLR1E, TPPP3, and WDR36, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane repolarization during ventricular cardiac muscle cell action potential activity versus POLR1E in BRCA (Pearson r = -0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	POLR1E →	-0.356	-0.067	.001	<.001	3	7
LSCC	TPPP3 →	+0.570	+0.064	<.001	<.001	3	6
BRCA	WDR36 →	-0.323	-0.074	<.001	<.001	3	6
BRCA	TBL3 →	-0.278	-0.071	<.001	<.001	3	6
LSCC	THOC6 →	-0.225	-0.068	<.001	<.001	3	6
GBM	UTP3 →	-0.281	-0.058	.003	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098915 vs POLR1E — BRCA

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