Membrane repolarization during atrial cardiac muscle cell action potential

Across TCGA patient cohorts, RNA activity of the Membrane repolarization during atrial cardiac muscle cell action potential pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EMC8, PLAC9, and PRKAR2B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane repolarization during atrial cardiac muscle cell action potential activity versus EMC8 in BRCA (Pearson r = -0.13).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	EMC8 →	+0.130	+0.048	.007	.002	3	5
HNSC	PLAC9 →	-0.694	-0.126	.001	<.001	3	5
HNSC	PRKAR2B →	-0.558	-0.110	<.001	<.001	3	5
COAD	CYB5B →	+0.369	+0.105	.001	<.001	3	5
BRCA	SERPINA5 →	-0.598	-0.072	.001	<.001	3	4
COAD	SNX6 →	-0.173	-0.104	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098914 vs EMC8 — BRCA

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