Regulation of cardiac muscle cell action potential involved in regulation of contraction

Across TCGA patient cohorts, RNA activity of the Regulation of cardiac muscle cell action potential involved in regulation of contraction pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CAMK2D, DPYD, and SVIL_S905, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cardiac muscle cell action potential involved in regulation of contraction activity versus CAMK2D in LUAD (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CAMK2D →	+0.460	+0.091	<.001	<.001	3	8
GBM	DPYD →	+0.752	+0.152	<.001	<.001	3	8
GBM	SVIL_S905 →	+1.103	+0.146	.009	.003	3	7
LUAD	TOP1 →	-0.344	-0.095	.001	<.001	3	7
UCEC	VCL →	+0.542	+0.111	<.001	<.001	3	7
UCEC	YME1L1 →	-0.364	-0.088	<.001	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098909 vs CAMK2D — LUAD

Explore this scatter interactively →