Regulation of cardiac muscle cell action potential involved in regulation of contraction

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of cardiac muscle cell action potential involved in regulation of contraction pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 8 member genes.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher Regulation of cardiac muscle cell action potential involved in regulation of contraction pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCS and SKCM, show the opposite pattern, with higher activity associated with better survival.

UCS, SKCM, and LGG are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Quartile	II,III,IV	0.769	0.367	.019	70	view →
SKCM	OS	Median	III,IV	0.795	0.612	<.001	49	view →
LGG	DFS	Tertile	All	0.303	0.503	<.001	48	view →
KIRP	DFS	Quartile	II,III,IV	1.000	0.524	<.001	38	view →
KIRC	DFS	Tertile	IV	0.421	0.746	.003	31	view →
UVM	DFS	Tertile	All	0.317	0.891	.004	25	view →
LAML	DFS	Median	All	0.443	0.676	.016	22	view →
KICH	DFS	Quartile	All	0.695	1.000	.007	17	view →
THYM	DFS	Median	All	0.966	0.681	.011	17	view →
CHOL	OS	Median	All	0.350	0.768	.013	12	view →
DLBC	OS	Median	II,III,IV	1.000	0.303	.013	10	view →
HNSC	OS	Tertile	II,III,IV	0.573	0.219	.011	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:0098909–UCS (OS)

Open the UCS breakdown →