Regulation of cardiac muscle cell action potential involved in regulation of contraction

Across TCGA patient cohorts, RNA activity of the Regulation of cardiac muscle cell action potential involved in regulation of contraction pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATG9B, SVEP1, and EPDR1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cardiac muscle cell action potential involved in regulation of contraction activity versus ATG9B in PDAC (Pearson r = -0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ATG9B →	-0.655	-0.074	.001	.006	3	4
BRCA	SVEP1 →	+1.434	+0.276	<.001	<.001	3	4
BRCA	EPDR1 →	+0.729	+0.290	<.001	.003	2	5
BRCA	SORBS1 →	+1.255	+0.180	<.001	.004	3	4
UCEC	MS4A2 →	+0.707	+0.103	<.001	<.001	3	4
GBM	CKS1BP3 →	-0.364	-0.524	.003	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098909 vs ATG9B — PDAC

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