Regulation of cardiac muscle cell action potential involved in regulation of contraction

Across TCGA cell cohorts, RNA activity of the Regulation of cardiac muscle cell action potential involved in regulation of contraction pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HLA-A, ANKRD30B, and CNPY4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HLA-A grouped by Regulation of cardiac muscle cell action potential involved in regulation of contraction-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	HLA-A →	+2.396	+0.728	.002	.001	3	4
PANCREAS	ANKRD30B →	-0.051	-0.802	.007	.006	3	3
LUNG_NSCLC_LUAD	CNPY4 →	-0.834	-0.579	<.001	.005	3	3
LUNG_NSCLC_LUAD	RNASE4 →	-1.094	-0.573	.001	.006	3	3
SKIN	WDR13 →	-0.665	-0.999	.007	<.001	3	3
SKIN	CLDN15 →	-0.957	-1.040	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HLA-A by Regulation of cardiac muscle cell action potential involved in regulation of contraction activity — BREAST

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