Regulation of cardiac muscle cell action potential involved in regulation of contraction

Across TCGA cell cohorts, RNA activity of the Regulation of cardiac muscle cell action potential involved in regulation of contraction pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ASIP, COL4A3, and CHST4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ASIP grouped by Regulation of cardiac muscle cell action potential involved in regulation of contraction-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ASIP →	+0.218	+0.266	.003	<.001	3	5
OESOPHAGUS	COL4A3 →	+0.132	+0.167	.004	.007	3	5
LARGE_INTESTINE	CHST4 →	+0.177	+0.162	<.001	<.001	3	4
SOFT_TISSUE	TRIM32 →	-0.201	-0.210	.007	.003	3	4
CNS	PREX2 →	+0.192	+0.224	.001	.007	3	4
BREAST	MIB1 →	-0.219	-0.161	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ASIP by Regulation of cardiac muscle cell action potential involved in regulation of contraction activity — LARGE_INTESTINE

Explore this box plot interactively →