Regulation of cardiac muscle cell action potential involved in regulation of contraction

Across TCGA cell cohorts, RNA activity of the Regulation of cardiac muscle cell action potential involved in regulation of contraction pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FN3K, SLC25A15, and CAV1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cardiac muscle cell action potential involved in regulation of contraction activity versus FN3K in SKIN (Pearson r = -0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	FN3K →	-1.722	-0.629	<.001	.002	3	5
SOFT_TISSUE	SLC25A15 →	-1.337	-0.452	<.001	.002	3	4
OESOPHAGUS	CAV1 →	+3.231	+0.372	.009	.003	2	5
LUNG_NSCLC_LUAD	NGF →	+1.186	+0.245	.001	.009	3	4
SKIN	LRPPRC →	-0.573	-0.684	<.001	<.001	3	4
SKIN	WDR61 →	-1.187	-0.893	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098909 vs FN3K — SKIN

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