Regulation of cardiac muscle cell action potential involved in regulation of contraction

Across TCGA cell cohorts, RNA activity of the Regulation of cardiac muscle cell action potential involved in regulation of contraction pathway is significantly associated with the protein abundance of multiple proteins, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CAV1, PEBP1, and PCBP1, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cardiac muscle cell action potential involved in regulation of contraction activity versus CAV1 in PANCREAS (Pearson r = 0.78).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CAV1 →	+3.897	+0.561	<.001	<.001	3	14
LUNG_NSCLC_LUSC	PEBP1 →	-3.397	-0.692	.006	<.001	3	10
LUNG_NSCLC_LUSC	PCBP1 →	-1.380	-0.642	<.001	<.001	3	10
LUNG_NSCLC_LUSC	DDI2 →	-2.386	-0.602	<.001	<.001	3	10
LUNG_NSCLC_LUSC	BOLA2 →	-2.970	-0.745	<.001	<.001	3	10
OESOPHAGUS	PPM1G →	-1.075	-0.345	.002	.003	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098909 vs CAV1 — PANCREAS

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