Regulation of cardiac muscle cell action potential

Across TCGA patient cohorts, RNA activity of the Regulation of cardiac muscle cell action potential pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are JUP, DSG2, and DSG2_T922, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cardiac muscle cell action potential activity versus JUP in OV (Pearson r = 0.50).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	JUP →	+0.614	+0.042	.001	<.001	3	7
HNSC	DSG2 →	+0.500	+0.067	<.001	<.001	3	5
HNSC	DSG2_T922 →	+0.328	+0.038	.005	.008	3	5
LUAD	PKP2 →	+0.857	+0.039	.002	.006	3	5
CCRCC	PKP2_S251 →	+1.022	+0.078	<.001	<.001	3	5
BRCA	TRIM29 →	+1.262	+0.046	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098901 vs JUP — OV

Explore this scatter interactively →