Regulation of cardiac muscle cell action potential

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of cardiac muscle cell action potential pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 29 member genes.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher Regulation of cardiac muscle cell action potential pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRC and KIRP, show the opposite pattern, with higher activity associated with better survival.

LUAD, DLBC, and ESCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.247	0.454	<.001	42	view →
DLBC	OS	Median	II,III,IV	0.393	0.928	.002	39	view →
ESCA	DFS	Median	II,III,IV	0.446	0.590	.036	18	view →
KIRC	DFS	Median	II,III,IV	0.640	0.358	.007	16	view →
LUSC	DFS	Quartile	III,IV	0.387	0.907	.019	15	view →
MESO	DFS	Median	IV	0.204	0.451	.024	15	view →
LIHC	OS	Tertile	III,IV	0.409	0.756	.006	15	view →
KIRP	OS	Quartile	III,IV	0.909	0.259	.013	14	view →
UCS	DFS	Tertile	IV	0.956	0.484	.024	12	view →
UVM	OS	Tertile	III,IV	0.305	0.832	.011	10	view →
BLCA	DFS	Median	All	0.558	0.653	.006	9	view →
THCA	DFS	Quartile	All	0.822	0.897	.024	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0098901–LUAD (OS)

Open the LUAD breakdown →