Regulation of cardiac muscle cell action potential

Across TCGA patient cohorts, RNA activity of the Regulation of cardiac muscle cell action potential pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPHK1, BTK, and TRIM2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cardiac muscle cell action potential activity versus SPHK1 in OV (Pearson r = -0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SPHK1 →	-1.008	-0.605	<.001	<.001	3	5
LSCC	BTK →	-0.533	-0.433	<.001	.004	3	5
LSCC	TRIM2 →	+0.856	+0.652	.001	.006	3	5
LSCC	PERP →	+1.431	+0.852	<.001	<.001	3	5
OV	LY86 →	-0.717	-0.624	.009	<.001	3	5
HNSC	PREX1 →	-0.777	-1.035	.002	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098901 vs SPHK1 — OV

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