Modification of postsynaptic actin cytoskeleton

Across TCGA patient cohorts, RNA activity of the Modification of postsynaptic actin cytoskeleton pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KANK2, JPT1, and AGO1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Modification of postsynaptic actin cytoskeleton activity versus KANK2 in BRCA (Pearson r = -0.07).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KANK2 →	-0.353	-0.027	.002	.008	3	7
HNSC	JPT1 →	+0.362	+0.077	<.001	.002	3	6
LUAD	AGO1 →	-0.152	-0.048	.003	<.001	3	6
LUAD	DNAJA1_S335 →	+0.445	+0.050	<.001	<.001	3	6
LSCC	LUM →	-0.407	-0.056	.004	.002	3	6
BRCA	RRP7A →	+0.231	+0.037	.004	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098885 vs KANK2 — BRCA

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