Modification of postsynaptic actin cytoskeleton

Across TCGA patient cohorts, RNA activity of the Modification of postsynaptic actin cytoskeleton pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BAIAP2, APH1A, and SSR2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Modification of postsynaptic actin cytoskeleton activity versus BAIAP2 in LSCC (Pearson r = -0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	BAIAP2 →	+0.925	+0.857	<.001	<.001	3	6
BRCA	APH1A →	-0.392	-0.790	<.001	.002	3	4
BRCA	SSR2 →	-0.315	-0.744	<.001	<.001	3	4
UCEC	CLK2 →	-0.531	-0.572	<.001	<.001	3	4
HNSC	IL36B →	+0.971	+1.014	<.001	<.001	3	4
LSCC	EPHA2 →	+0.760	+0.730	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098885 vs BAIAP2 — LSCC

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