Modification of postsynaptic actin cytoskeleton

Across TCGA cell cohorts, RNA activity of the Modification of postsynaptic actin cytoskeleton pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTTN, CMYA5, and DDX60L, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Modification of postsynaptic actin cytoskeleton activity versus CTTN in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	CTTN →	+2.045	+0.184	<.001	<.001	2	12
URINARY_TRACT	CMYA5 →	+0.811	+0.094	.004	.003	3	8
BREAST	DDX60L →	+1.267	+0.106	.005	.004	3	8
SOFT_TISSUE	RPL9 →	-1.033	-0.095	<.001	<.001	3	8
OESOPHAGUS	RPL15 →	-0.842	-0.141	<.001	.001	3	8
BREAST	POLD4 →	+1.223	+0.129	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098885 vs CTTN — UPPER_AERODIGESTIVE_TRACT

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