Postsynaptic neurotransmitter receptor internalization

Across TCGA patient cohorts, RNA activity of the Postsynaptic neurotransmitter receptor internalization pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ISLR, CNRIP1, and RSU1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Postsynaptic neurotransmitter receptor internalization activity versus ISLR in CCRCC (Pearson r = 0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ISLR →	+0.772	+0.058	<.001	<.001	3	8
OV	CNRIP1 →	+0.645	+0.050	<.001	<.001	3	7
BRCA	RSU1 →	+0.342	+0.039	.002	<.001	3	7
LSCC	TBC1D2B →	+0.289	+0.069	<.001	<.001	3	7
BRCA	CNN2 →	+0.571	+0.040	<.001	<.001	3	7
GBM	GUCY1A1 →	+0.552	+0.093	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098884 vs ISLR — CCRCC

Explore this scatter interactively →