Postsynaptic neurotransmitter receptor internalization

Across TCGA pan-cancer cohorts, RNA activity of the Postsynaptic neurotransmitter receptor internalization pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 24 member genes.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher Postsynaptic neurotransmitter receptor internalization pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as PCPG and SKCM, show the opposite pattern, with higher activity associated with better survival.

ACC, KIRC, and OV are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Quartile	All	0.090	0.615	<.001	82	view →
KIRC	OS	Quartile	II,III,IV	0.482	0.749	.004	44	view →
OV	OS	Tertile	III,IV	0.633	0.742	.006	38	view →
PCPG	DFS	Median	All	1.000	0.814	<.001	23	view →
CHOL	OS	Tertile	II,III,IV	0.199	0.795	.002	23	view →
READ	OS	Median	All	0.525	1.000	.001	17	view →
SKCM	OS	Quartile	III,IV	0.586	0.244	.001	16	view →
MESO	OS	Quartile	All	0.469	0.259	.014	15	view →
PRAD	DFS	Tertile	All	0.899	0.722	.012	14	view →
SARC	DFS	Tertile	All	0.222	0.572	<.001	10	view →
ESCA	DFS	Tertile	II,III,IV	0.431	1.000	.027	9	view →
KIRP	DFS	Median	All	0.812	0.892	.030	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:0098884–ACC (DFS)

Open the ACC breakdown →