Maintenance of postsynaptic specialization structure

Across TCGA patient cohorts, RNA activity of the Maintenance of postsynaptic specialization structure pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SHANK2, SHANK2_S96, and SEC11C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of postsynaptic specialization structure activity versus SHANK2 in HNSC (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SHANK2 →	+0.425	+0.050	.006	<.001	3	5
BRCA	SHANK2_S96 →	+0.896	+0.041	.002	.006	3	5
GBM	SEC11C →	-0.365	-0.084	<.001	<.001	3	5
LSCC	ARVCF_S915 →	-0.832	-0.039	<.001	<.001	3	4
LSCC	SHANK2_S1330 →	+0.686	+0.059	.001	<.001	3	4
LSCC	RASA1 →	+0.231	+0.042	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098880 vs SHANK2 — HNSC

Explore this scatter interactively →