Maintenance of postsynaptic specialization structure

Across TCGA pan-cancer cohorts, RNA activity of the Maintenance of postsynaptic specialization structure pathway is associated with patient survival in 19 of 34 cancer lineages. Pathway activity is summarized from the expression of its 8 member genes.

The strongest signal is observed in brain lower grade glioma (LGG), where higher Maintenance of postsynaptic specialization structure pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LGG and KIRC, show the opposite pattern, with higher activity associated with better survival.

LGG, KIRC, and ACC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.542	0.315	<.001	52	view →
KIRC	OS	Tertile	All	0.766	0.557	<.001	47	view →
ACC	DFS	Median	IV	0.495	0.066	.001	42	view →
DLBC	DFS	Quartile	All	0.624	1.000	.006	39	view →
CESC	OS	Quartile	III,IV	0.877	0.519	.010	32	view →
MESO	OS	Tertile	IV	0.316	0.917	.004	30	view →
READ	DFS	Tertile	III,IV	0.499	0.895	.002	23	view →
TGCT	DFS	Quartile	All	0.946	0.703	.016	12	view →
BLCA	DFS	Quartile	All	0.108	0.446	.013	12	view →
LUSC	OS	Quartile	II,III,IV	0.840	0.654	.011	10	view →
THCA	OS	Median	II,III,IV	0.934	0.985	.023	7	view →
CHOL	DFS	Tertile	All	0.191	0.519	.018	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

GO:0098880–LGG (OS)

Open the LGG breakdown →