Maintenance of postsynaptic specialization structure

Across TCGA cell cohorts, RNA activity of the Maintenance of postsynaptic specialization structure pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKCZ, PIK3R3, and DUS4L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRKCZ grouped by Maintenance of postsynaptic specialization structure-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PRKCZ →	+0.148	+1.247	.001	<.001	3	4
OESOPHAGUS	PIK3R3 →	+0.115	+1.138	<.001	.001	3	3
KIDNEY	DUS4L →	-0.222	-0.289	.002	<.001	3	3
OESOPHAGUS	SYNJ2 →	-0.161	-1.157	<.001	<.001	3	3
BREAST	CEBPG →	-0.260	-0.888	.001	<.001	3	3
SKIN	FAM20C →	+0.265	+1.425	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRKCZ by Maintenance of postsynaptic specialization structure activity — BLOOD_Leukemia

Explore this box plot interactively →