Maintenance of postsynaptic specialization structure

Across TCGA cell cohorts, RNA activity of the Maintenance of postsynaptic specialization structure pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GATA2, TARBP2, and MAP3K1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of postsynaptic specialization structure activity versus GATA2 in BLOOD_Leukemia (Pearson r = -0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GATA2 →	-3.346	-0.702	.002	.007	3	5
SKIN	TARBP2 →	-0.508	-1.062	.002	.004	3	5
BONE	MAP3K1 →	+1.812	+1.542	<.001	<.001	3	5
BLOOD_Leukemia	PDSS2 →	-0.809	-0.882	<.001	.003	3	4
LUNG_NSCLC_LUSC	ZBTB24 →	-0.592	-1.199	.002	.001	2	5
LIVER	AFAP1L2 →	+2.735	+1.129	.003	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098880 vs GATA2 — BLOOD_Leukemia

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