Vesicle-mediated transport to the plasma membrane

Across TCGA cell cohorts, RNA activity of the Vesicle-mediated transport to the plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HBEGF, PXN, and RHOBTB3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vesicle-mediated transport to the plasma membrane activity versus HBEGF in LIVER (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	HBEGF →	+1.908	+0.209	.001	.002	3	5
LIVER	PXN →	+1.702	+0.296	<.001	<.001	3	5
LIVER	RHOBTB3 →	+2.197	+0.273	.004	.007	1	6
LIVER	WNK2 →	-2.808	-0.216	.007	.001	3	4
UPPER_AERODIGESTIVE_TRACT	PUM2 →	-0.792	-0.202	.005	.004	3	4
PANCREAS	ADGRL1 →	-1.745	-0.145	.003	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098876 vs HBEGF — LIVER

Explore this scatter interactively →