Bone growth

Across TCGA patient cohorts, RNA activity of the Bone growth pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCDH7, ZFPM2, and KDM5B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Bone growth activity versus PCDH7 in BRCA (Pearson r = 0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PCDH7 →	+0.831	+0.841	<.001	<.001	3	6
BRCA	ZFPM2 →	+0.698	+0.792	<.001	<.001	3	5
LSCC	KDM5B →	+0.449	+0.585	.002	.008	2	5
BRCA	GJA1 →	+1.455	+0.621	.001	<.001	3	4
COAD	FBXO32 →	+0.797	+0.294	.001	.004	3	4
LSCC	PRKD1 →	+0.440	+0.614	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098868 vs PCDH7 — BRCA

Explore this scatter interactively →