Bone growth

Across TCGA cell cohorts, RNA activity of the Bone growth pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NANOS1, CRTAP, and AZIN2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NANOS1 grouped by Bone growth-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	NANOS1 →	-1.192	-0.696	.001	.006	3	4
LUNG_NSCLC_LUSC	CRTAP →	-1.429	-1.173	.002	.004	3	4
LUNG_NSCLC_LUSC	AZIN2 →	-1.931	-1.160	.002	.007	3	3
CNS	BCOR →	+0.955	+0.984	.005	.001	3	3
LUNG_NSCLC_LUSC	GALNT3 →	+3.240	+1.212	.004	.002	3	3
LUNG_NSCLC_LUSC	PRRG4 →	+2.206	+1.433	.008	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NANOS1 by Bone growth activity — SKIN

Explore this box plot interactively →