Bone growth

Across TCGA cell cohorts, RNA activity of the Bone growth pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP2R1A, HDAC1, and SP8, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPP2R1A grouped by Bone growth-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PPP2R1A →	+0.710	+1.861	.004	.002	3	3
OESOPHAGUS	HDAC1 →	+0.171	+1.820	.001	<.001	3	3
BREAST	SP8 →	+0.183	+0.837	<.001	.001	3	3
BREAST	BDKRB2 →	+0.251	+0.925	<.001	.005	3	3
BLOOD_Leukemia	PML →	+0.250	+0.216	.002	.005	2	3
LUNG_SCLC	IFIT1B →	+0.217	+1.117	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPP2R1A by Bone growth activity — SOFT_TISSUE

Explore this box plot interactively →