Bone growth

Across TCGA cell cohorts, RNA activity of the Bone growth pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FGFRL1, SLC50A1, and LGALS9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Bone growth activity versus FGFRL1 in BLOOD_Lymphoma (Pearson r = -0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	FGFRL1 →	-1.284	-1.009	.009	.003	3	4
OESOPHAGUS	SLC50A1 →	-1.447	-1.917	.007	<.001	3	4
LARGE_INTESTINE	LGALS9 →	-5.830	-2.135	<.001	<.001	3	3
PANCREAS	LXN →	-2.093	-1.923	.008	<.001	2	4
BLOOD_Leukemia	NECTIN2 →	-1.928	-0.631	.002	.005	3	3
LARGE_INTESTINE	KIF13A →	-2.117	-2.035	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098868 vs FGFRL1 — BLOOD_Lymphoma

Explore this scatter interactively →