Modulation of inhibitory postsynaptic potential

Across TCGA cell cohorts, RNA activity of the Modulation of inhibitory postsynaptic potential pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM170B, KIAA0930, and RABEP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMEM170B grouped by Modulation of inhibitory postsynaptic potential-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TMEM170B →	+2.351	+1.362	<.001	.001	3	4
BLOOD_Leukemia	KIAA0930 →	+2.977	+1.720	<.001	<.001	3	4
LUNG_SCLC	RABEP1 →	+0.751	+0.955	.001	.006	3	3
UPPER_AERODIGESTIVE_TRACT	MYCBP2 →	+1.276	+1.978	<.001	.002	3	3
OVARY	GTF2H3 →	+0.556	+0.969	.001	.003	3	3
LARGE_INTESTINE	DYRK3 →	+0.933	+1.194	.007	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMEM170B by Modulation of inhibitory postsynaptic potential activity — BLOOD_Leukemia

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