Modulation of excitatory postsynaptic potential

Across TCGA cell cohorts, RNA activity of the Modulation of excitatory postsynaptic potential pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF4A3, SSH1, and SRD5A3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EIF4A3 grouped by Modulation of excitatory postsynaptic potential-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	EIF4A3 →	-0.352	-0.199	.002	<.001	3	5
PANCREAS	SSH1 →	-0.372	-0.258	<.001	.001	3	4
SOFT_TISSUE	SRD5A3 →	-0.240	-0.393	.002	.008	3	3
SOFT_TISSUE	CYBC1 →	+0.279	+0.449	.006	.006	2	4
PANCREAS	MTMR3 →	-0.140	-0.223	<.001	.002	3	3
PANCREAS	DMGDH →	-0.157	-0.307	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EIF4A3 by Modulation of excitatory postsynaptic potential activity — BREAST

Explore this box plot interactively →