Modulation of excitatory postsynaptic potential

Across TCGA pan-cancer cohorts, RNA activity of the Modulation of excitatory postsynaptic potential pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 49 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Modulation of excitatory postsynaptic potential pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UVM and LGG, show the opposite pattern, with higher activity associated with better survival.

UVM, LGG, and LUAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	III,IV	0.838	0.276	.001	64	view →
LGG	OS	Median	All	0.540	0.352	<.001	47	view →
LUAD	OS	Median	II,III,IV	0.339	0.170	.002	40	view →
LIHC	OS	Tertile	All	0.694	0.428	.004	35	view →
CESC	OS	Quartile	All	0.793	0.951	<.001	22	view →
ACC	DFS	Tertile	IV	0.092	0.630	.002	22	view →
KIRC	DFS	Tertile	IV	0.319	0.671	.007	20	view →
SARC	DFS	Tertile	All	0.665	0.345	<.001	15	view →
THCA	OS	Median	III,IV	0.946	0.762	.015	13	view →
THYM	OS	Quartile	II,III,IV	0.879	1.000	.013	9	view →
HNSC	OS	Median	All	0.717	0.805	.005	9	view →
STAD	DFS	Median	IV	0.171	0.670	.006	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0098815–UVM (DFS)

Open the UVM breakdown →