Xenophagy

Across TCGA cell cohorts, RNA activity of the Xenophagy pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VCAN, MANSC1, and C1QTNF1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VCAN grouped by Xenophagy-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	VCAN →	-3.692	-1.034	<.001	<.001	3	5
PANCREAS	MANSC1 →	-1.854	-1.265	.007	.001	3	4
BONE	C1QTNF1 →	-1.363	-1.987	.001	<.001	3	4
LARGE_INTESTINE	SLC2A4 →	+0.677	+0.953	<.001	<.001	3	3
BLOOD_Myeloma	ASIC1 →	-2.066	-1.271	<.001	.001	3	3
BLOOD_Myeloma	TFAP2E →	+1.016	+1.599	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VCAN by Xenophagy activity — SOFT_TISSUE

Explore this box plot interactively →