Xenophagy

Across TCGA cell cohorts, RNA activity of the Xenophagy pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JUN, CREB3, and FLYWCH2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Xenophagy activity versus JUN in BLOOD_Lymphoma (Pearson r = 0.84).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	JUN →	+2.734	+1.700	.009	<.001	3	4
BLOOD_Lymphoma	CREB3 →	+0.564	+1.689	.001	.007	3	3
BLOOD_Lymphoma	FLYWCH2 →	+1.320	+1.696	.006	<.001	3	3
BLOOD_Lymphoma	MBOAT1 →	+3.087	+2.099	.005	<.001	3	3
BLOOD_Lymphoma	FECH →	+1.456	+1.847	.004	<.001	3	3
LUNG_NSCLC_LUAD	TM4SF19 →	-2.624	-0.393	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098792 vs JUN — BLOOD_Lymphoma

Explore this scatter interactively →