Obsolete ncRNA transcription

pathway activity — cross-omics
GO:0098781Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Obsolete ncRNA transcription pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PDIA4, ACBD5, and GORASP2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUADPDIA4 →-0.294-0.023.006.00136
PDACACBD5 →-0.368-0.022.003<.00136
CCRCCGORASP2 →-0.175-0.021.001.00236
BRCAACBD3 →-0.154-0.020.003.00136
LSCCSEC24A →-0.327-0.032.001<.00135
LSCCSTT3B →-0.276-0.036.002<.00135
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration