Response to mitochondrial depolarisation

Across TCGA patient cohorts, RNA activity of the Response to mitochondrial depolarisation pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAF1, NFAT5, and PHF12, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to mitochondrial depolarisation activity versus TAF1 in THYM (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	TAF1 →	+1.282	+0.072	<.001	<.001	3	34
THYM	NFAT5 →	+1.999	+0.067	<.001	<.001	3	33
DLBC	PHF12 →	+0.872	+0.058	<.001	<.001	3	33
UVM	MTR →	+1.354	+0.033	<.001	<.001	3	33
THYM	ZNF137P →	+1.198	+0.066	<.001	<.001	3	33
UVM	ATG14 →	+1.263	+0.034	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098780 vs TAF1 — THYM

Explore this scatter interactively →