Response to mitochondrial depolarisation

Across TCGA cell cohorts, RNA activity of the Response to mitochondrial depolarisation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIM38, GRSF1, and OS9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRIM38 grouped by Response to mitochondrial depolarisation-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TRIM38 →	-0.725	-1.299	<.001	<.001	3	4
KIDNEY	GRSF1 →	+0.712	+1.331	.001	.003	3	4
BLOOD_Leukemia	OS9 →	-0.635	-1.267	.003	.003	3	4
BLOOD_Leukemia	FAM160A2 →	-0.819	-1.529	.009	<.001	3	4
SOFT_TISSUE	SLC25A38 →	-0.564	-1.602	.004	<.001	3	4
BREAST	NXPE3 →	+0.904	+0.841	.006	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRIM38 by Response to mitochondrial depolarisation activity — PANCREAS

Explore this box plot interactively →