Skin epidermis development

Across TCGA patient cohorts, RNA activity of the Skin epidermis development pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SRP19, PSME2, and KRT17, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Skin epidermis development activity versus SRP19 in BRCA (Pearson r = -0.19).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SRP19 →	-0.299	-0.023	<.001	.002	3	6
LSCC	PSME2 →	-0.396	-0.042	<.001	<.001	3	6
PDAC	KRT17 →	+1.393	+0.036	<.001	<.001	3	6
BRCA	SRRM2_S1424 →	-0.755	-0.027	<.001	<.001	3	5
GBM	RFC1_S368 →	-0.591	-0.033	<.001	<.001	3	5
COAD	SEC16A_S2037 →	-0.354	-0.025	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098773 vs SRP19 — BRCA

Explore this scatter interactively →