Skin epidermis development

Across TCGA pan-cancer cohorts, RNA activity of the Skin epidermis development pathway is associated with patient survival in 19 of 34 cancer lineages. Pathway activity is summarized from the expression of its 127 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher Skin epidermis development pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and ESCA, show the opposite pattern, with higher activity associated with better survival.

HNSC, READ, and LGG are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	II,III,IV	0.489	0.258	<.001	104	view →
READ	DFS	Tertile	IV	0.223	0.758	<.001	55	view →
LGG	DFS	Median	All	0.274	0.477	<.001	54	view →
MESO	OS	Tertile	All	0.245	0.480	.002	49	view →
STAD	DFS	Tertile	II,III,IV	0.216	0.491	.008	42	view →
DLBC	DFS	Tertile	All	0.438	0.951	.004	33	view →
UVM	OS	Median	III,IV	0.415	0.787	.002	27	view →
ESCA	DFS	Median	III,IV	0.470	0.238	.008	23	view →
ACC	OS	Tertile	All	0.594	0.925	.015	23	view →
LUAD	OS	Median	All	0.721	0.847	.005	21	view →
SCLC	DFS	Tertile	All	1.000	0.619	.004	20	view →
LUSC	OS	Quartile	II,III,IV	0.505	0.285	.018	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

GO:0098773–HNSC (DFS)

Open the HNSC breakdown →