Skin epidermis development

Across TCGA patient cohorts, RNA activity of the Skin epidermis development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LINC01614, PLAU, and COL11A1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Skin epidermis development activity versus LINC01614 in BRCA (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LINC01614 →	+1.218	+0.176	<.001	.002	3	5
LUAD	PLAU →	+1.073	+0.153	<.001	<.001	3	5
LUAD	COL11A1 →	+1.262	+0.119	.003	.004	3	5
PDAC	PRR16 →	+0.411	+0.221	.003	.001	3	5
PDAC	LINC01929 →	+1.136	+0.197	<.001	.002	3	5
PDAC	PRRX1 →	+0.813	+0.225	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098773 vs LINC01614 — BRCA

Explore this scatter interactively →