Skin epidermis development

Across TCGA cell cohorts, RNA activity of the Skin epidermis development pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUCKS1, UBXN2A, and YME1L1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Skin epidermis development activity versus NUCKS1 in LARGE_INTESTINE (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NUCKS1 →	+1.314	+0.237	<.001	.002	3	5
BLOOD_Leukemia	UBXN2A →	+0.727	+0.286	.001	<.001	3	4
LUNG_NSCLC_LUSC	YME1L1 →	+0.659	+0.363	.001	.007	3	4
UPPER_AERODIGESTIVE_TRACT	DCLRE1B →	+0.831	+0.220	<.001	.003	3	4
BLOOD_Leukemia	MPRIP →	+0.776	+0.158	.001	.008	2	5
LARGE_INTESTINE	ZNF462 →	+1.113	+0.162	.009	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098773 vs NUCKS1 — LARGE_INTESTINE

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