Cell aggregation

Across TCGA patient cohorts, RNA activity of the Cell aggregation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIR29B2CHG, NKX3-2, and CILP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell aggregation activity versus MIR29B2CHG in GBM (Pearson r = -0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MIR29B2CHG →	-0.418	-0.537	.002	.007	3	4
COAD	NKX3-2 →	+0.630	+0.338	<.001	<.001	3	4
COAD	CILP2 →	+0.509	+0.356	.004	.002	3	4
OV	PTH1R →	+0.646	+0.383	.002	.003	3	4
COAD	GAS1 →	+0.922	+0.334	.009	.004	3	4
UCEC	MIR210HG →	+0.841	+0.698	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098743 vs MIR29B2CHG — GBM

Explore this scatter interactively →