Cell aggregation

Across TCGA cell cohorts, RNA activity of the Cell aggregation pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VWA2, SULT4A1, and SCARB1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VWA2 grouped by Cell aggregation-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	VWA2 →	-0.175	-1.174	.005	.001	3	4
BLOOD_Lymphoma	SULT4A1 →	+0.403	+1.400	.001	.001	3	3
LUNG_NSCLC_LUSC	SCARB1 →	-0.141	-1.280	.001	.001	3	3
OESOPHAGUS	CROT →	-0.171	-1.346	.006	<.001	3	3
LUNG_SCLC	TNFRSF8 →	-0.245	-1.495	.004	.003	3	3
LUNG_SCLC	PMPCA →	-0.298	-1.460	.007	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VWA2 by Cell aggregation activity — LUNG_SCLC

Explore this box plot interactively →