Macromolecule depalmitoylation

Across TCGA patient cohorts, RNA activity of the Macromolecule depalmitoylation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CNRIP1, RPS8, and SHANK3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Macromolecule depalmitoylation activity versus CNRIP1 in BRCA (Pearson r = 0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CNRIP1 →	+0.416	+0.034	.004	.001	3	6
LUAD	RPS8 →	-0.200	-0.036	<.001	.002	3	6
GBM	SHANK3 →	+0.480	+0.051	<.001	<.001	3	5
PDAC	STXBP1 →	+0.246	+0.042	.003	<.001	3	5
PDAC	TMOD2 →	+0.269	+0.039	<.001	<.001	3	5
LUAD	CCDC6_S52 →	-0.753	-0.047	.001	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098734 vs CNRIP1 — BRCA

Explore this scatter interactively →