Macromolecule depalmitoylation

Across TCGA patient cohorts, RNA activity of the Macromolecule depalmitoylation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABHD12, TIRAP, and P2RX2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Macromolecule depalmitoylation activity versus ABHD12 in LSCC (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ABHD12 →	+0.342	+0.088	.001	<.001	3	5
CCRCC	TIRAP →	+0.312	+0.099	<.001	.003	3	3
CCRCC	P2RX2 →	+0.097	+0.109	.005	<.001	3	3
CCRCC	CTF2P →	+0.278	+0.116	.005	.003	3	3
OV	PIK3CB →	+0.592	+0.129	.002	.005	3	3
GBM	LRRIQ1 →	-0.877	-0.081	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098734 vs ABHD12 — LSCC

Explore this scatter interactively →