Macromolecule depalmitoylation

Across TCGA cell cohorts, RNA activity of the Macromolecule depalmitoylation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLDN7, WTIP, and TMEM258, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Macromolecule depalmitoylation activity versus CLDN7 in PANCREAS (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CLDN7 →	+4.235	+0.252	<.001	.001	3	5
LUNG_NSCLC_LUAD	WTIP →	-1.664	-0.412	<.001	.005	3	4
PANCREAS	TMEM258 →	+0.636	+0.153	.003	<.001	3	4
KIDNEY	HHATL →	+0.067	+0.270	.003	.009	3	3
KIDNEY	DUSP5 →	+2.035	+0.258	.002	.008	3	3
PANCREAS	S100A14 →	+3.029	+0.133	.003	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098734 vs CLDN7 — PANCREAS

Explore this scatter interactively →