Sodium ion import across plasma membrane

Across TCGA patient cohorts, RNA activity of the Sodium ion import across plasma membrane pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PCDH1, BCAS1, and SLC9A1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sodium ion import across plasma membrane activity versus PCDH1 in BRCA (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PCDH1 →	+0.401	+0.038	.005	<.001	3	7
PDAC	BCAS1 →	+1.192	+0.095	<.001	<.001	3	6
OV	SLC9A1 →	+0.396	+0.049	<.001	<.001	3	6
HNSC	SAP30 →	-0.400	-0.056	<.001	.003	3	5
GBM	TOM1L2 →	+0.415	+0.087	<.001	<.001	3	5
GBM	BCAS1_S399 →	+0.989	+0.086	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098719 vs PCDH1 — BRCA

Explore this scatter interactively →