L-glutamate import across plasma membrane

Across TCGA patient cohorts, RNA activity of the L-glutamate import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HCN2, LRP4, and UNC5A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-glutamate import across plasma membrane activity versus HCN2 in GBM (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HCN2 →	+0.837	+0.321	.005	<.001	3	4
GBM	LRP4 →	+0.711	+0.282	<.001	<.001	3	3
GBM	UNC5A →	+0.795	+0.255	<.001	.001	3	3
BRCA	HAO2 →	+0.798	+0.568	.007	.003	3	3
BRCA	PDZD8 →	+0.439	+0.522	.004	.001	3	3
GBM	SNPH →	+0.764	+0.376	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098712 vs HCN2 — GBM

Explore this scatter interactively →