L-glutamate import across plasma membrane

Across TCGA patient cohorts, RNA activity of the L-glutamate import across plasma membrane pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DDX46_S804, ATP1A2, and SIN3A_S860, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-glutamate import across plasma membrane activity versus DDX46_S804 in BRCA (Pearson r = 0.01).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DDX46_S804 →	-0.475	-0.747	<.001	<.001	3	5
GBM	ATP1A2 →	+1.017	+0.503	<.001	<.001	3	4
OV	SIN3A_S860 →	-0.550	-0.455	<.001	.001	3	3
OV	CHAMP1_S603 →	-0.885	-0.397	<.001	<.001	3	3
HNSC	HNRNPUL1_S194 →	-0.693	-0.629	<.001	<.001	3	3
BRCA	RBSN_S684 →	-0.960	-0.416	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098712 vs DDX46_S804 — BRCA

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